唐元清, 吴克美, 冯孝章, 黄量. 2-烯基-4(1H)-喹诺酮的合成及生物活性研究J. 药学学报, 1998, 33(4): 269-274.
引用本文: 唐元清, 吴克美, 冯孝章, 黄量. 2-烯基-4(1H)-喹诺酮的合成及生物活性研究J. 药学学报, 1998, 33(4): 269-274.
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Tang Yuanqing, Wu Kemei, Feng Xiaozhang , Huang Liang, . STUDIES ON SYNTHESIS AND BIOACTIVITY OF 2-ALKENYL-4(1H)-QUINOLONEJ. Acta Pharmaceutica Sinica, 1998, 33(4): 269-274.
Citation: Tang Yuanqing, Wu Kemei, Feng Xiaozhang , Huang Liang, . STUDIES ON SYNTHESIS AND BIOACTIVITY OF 2-ALKENYL-4(1H)-QUINOLONEJ. Acta Pharmaceutica Sinica, 1998, 33(4): 269-274.
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2-烯基-4(1H)-喹诺酮的合成及生物活性研究

STUDIES ON SYNTHESIS AND BIOACTIVITY OF 2-ALKENYL-4(1H)-QUINOLONE

    摘要
  • 摘要: 采用两种方法合成了3个2-烯基-4(1H)-喹诺酮(I～II),其中化合物II是从吴茱萸中分离得到的新化合物,其余2个化合物尚未见文献报道。并对所合成的化合物及中间体进行了初步药理试验,表明有一定的扩张血管和抗菌作用。

     

    Abstract: Three 2-alkenyl-4(1H)-quinolone compounds(I～III) were synthesized by two methods. III is a new compound fromEvodia rutaecarpa and was synthesized through the reaction of the aldehyde intermediate(5) with Wittig reagent.The other two compounds were synthesized for the first time.These compounds showed vasodilating and antibacteria effects in pharmacological tests.

     

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