海芒果Cerbera odollam果仁中强心甙的分离鉴定

THE SEPARATION AND IDENTIFICATION OF CARDIAC GLYCOSIDES IN THE KERNAL OF CERBERA ODOLLAM

摘要: 从海南岛产的海芒果Cerbera odollam果仁中分离到四种强心多糖甙monoacetyl-the-vetinB(Ⅰ)⁽¹⁾ thevetin B(Ⅲ)⁽²⁾及它们的7β,8β环氧衍生物tanghinoside(Ⅱ)⁽³⁾ desacetyl-tanghinoside(Ⅳ)。经果仁中的酶水介获得相应四个单糖甙Cerberin(Ⅴ)⁽⁴⁾ neriifolin(Ⅶ)⁽⁵⁾ tang hinin(Ⅵ)⁽⁶⁾ desacetyl-tanghinin(Ⅷ)⁽⁶⁾ tanghinoside,tanghinin及desacetyl-tanghinin以前未从Cerbera odollam中分到过。甙Ⅳ为一新甙。

Abstract: Four cardiac glycosides (Ⅰ, Ⅱ, Ⅲ, Ⅳ) were isolated from the kernal of Cerbera odollam growing in Hai-Nan Island. They were identified as monoacetyl-thevetin B (Ⅰ), thevetin B (Ⅲ), and their 7,8,-epoxide derivatives which were tanghinoside (Ⅱ) and desacetyl-tanghinoslde (Ⅳ).By enzymatic hydrolysis with the enzyme existing in the kernal four monoglycosides, cerberin (Ⅴ), neriifolin (Ⅶ), tanghinin (Ⅵ) and desacetyl-tanghinin (Ⅷ) were obtained respectively.Tanghinoside (Ⅱ), tanghinin (Ⅵ) and desacetyl-tanghinin (Ⅷ) had not been isolated from Gerbera odollam previously.Desacetyl-tanghinoside (Ⅳ) was a new compound.