通过交联度控制<em>&beta;-</em>环糊精聚合物对药物的载入与释放

通过交联度控制β-环糊精聚合物对药物的载入与释放

摘要:
本研究使用具有不同交联度 (CLD) 的β-环糊精聚合物 (β-CDP) 为载体与布洛芬形成包合物, 考察β-CDP结构和组成对药物载入和释放的影响。通过FT-IR和¹³C NMR确定β-CDP结构特征。结果表明在β-CDP中仍保留β-CD的原有结构特征。β-CDP的CLD是决定药物载入及释放的重要因素, 增加β-CDP的CLD会使药物的载入量减少, 释放量增大。

Abstract:
The purpose of the present study is to use β-cyclodextrin polymers (β-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of β-CDP on its drug loading and release behaviors. A series of β-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and ¹³C NMR spectrum. The β-CDPwas systemically characterized for the relation between the CLD of β-CDPand the drug loading and release as well. The results of FT-IR and ¹³C NMR showed that similar peak-shaped vibration of β-CDP and β-CD implies that the polymer keeps the original characteristic structure of β-CD. The CLD of the β-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.