罗娅林, 杨祯祥, 彭司勋. N-(2-巯基吡啶-3-甲酰)-N-烃基甘氨酸及其双硫化合物的合成J. 药学学报, 1990, 25(5): 374-378.
引用本文: 罗娅林, 杨祯祥, 彭司勋. N-(2-巯基吡啶-3-甲酰)-N-烃基甘氨酸及其双硫化合物的合成J. 药学学报, 1990, 25(5): 374-378.
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YL Luo, ZX Yang , SX Peng, . SYNTHESIS OF N-(2-MERCAPTOPYRIDYL-3-FORMYL)-N-ALKYL GLYCINE AND THE CORRESPONDING DISULFIDESJ. Acta Pharmaceutica Sinica, 1990, 25(5): 374-378.
Citation: YL Luo, ZX Yang , SX Peng, . SYNTHESIS OF N-(2-MERCAPTOPYRIDYL-3-FORMYL)-N-ALKYL GLYCINE AND THE CORRESPONDING DISULFIDESJ. Acta Pharmaceutica Sinica, 1990, 25(5): 374-378.
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N-(2-巯基吡啶-3-甲酰)-N-烃基甘氨酸及其双硫化合物的合成

SYNTHESIS OF N-(2-MERCAPTOPYRIDYL-3-FORMYL)-N-ALKYL GLYCINE AND THE CORRESPONDING DISULFIDES

    摘要
  • Abstract: N-(2-mercaptopyridyl-3-formyl)-N-alkyl glycine Ⅰ1～8)were synthesized by the condensation of 2-mercaptopyridyl-3-formyl chloride with ethyl N-alkyl glycinate followed by hydrolysis. The corresponding disulfides(Ⅱ1～7) were obtained by the oxidation of compounds Ⅰ1～7 with hydrogen peroxide(1%)in weak alkali medium below 10℃ In preliminary tests, some compounds showed inhibitory activity of ACE in vitro.

     

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