Abstract: Liver fibrosis is a pathological process of the excessive accumulation of extracellular matrix, especially collagen α1 (I) in liver. Ultimately, hepatic fibrosis leads to cirrhosis or hepatic failure. Liver fibrosis and early cirrhosis can be reversed, thus control of the development of liver fibrosis is very important for preventive treatment of cirrhosis and hepatic failure. This is a review of potential targets for anti-hepatic fibrosis based on plenty of publications, including TGF-β1 and integrin α_V and so on, aimed at providing novel therapeutic targets in liver fibrosis.