丹参中抑制血小板聚集的活性成分
PLATELET AGGREGATION INHIBITORS FROM SALVIA MILTIORRHIZA BUNGE
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摘要: 从中药丹参(Salvia miltiorrhiza Bunge)的根中获得5种成分,经鉴定3种为已知物即丹参新酮、铁锈醇及Ro-090680,另2种为新化合物,命名为△1丹参新酮与△1-丹参酮ⅡA并观察了它们抑制血小板的聚集活性。Abstract: Five constituents were isolated from Dan-Shen (Salvia miltiorrhiza). Three of them were identified as miltirone (Ⅱ), ferruginol (Ⅰ) and Ro090680 (Ⅲ). The two others were named △1-dehydromiltirone and △1-dehydrotanshinone ⅡA. Ro-090680 has been known as a potent inhibitor of rabbit platelet aggregation in vitro. Related tricyclic diterpenoids such as miltirone and ferruginol were also found to have the same activity.
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