藏药细果角茴香的化学研究

CHEMICAL STUDY ON A TRADITIONAL TIBETAN DRUG HYPECOUM LEPTOCARPUM

摘要: 从藏药细果角茴香(Hypecoum leptocarpum Hook.f.et Thoms.)中分离出四个结晶性生物碱:碱Ⅰ、碱Ⅱ、碱Ⅲ和碱Ⅳ。根据物理常数测定和光谱分析结果,证明碱Ⅰ为原阿片碱(protopine)、碱Ⅱ为隐品碱(cryptopine)、碱Ⅲ为oxyhydrastinine;而碱Ⅳ为一新生物碱,命名角茴香碱(hypecoumine),其结构初步推定如(1)式所示。

Abstract: Four alkaloids were isolated from a traditional Tibetan drug Hypecoum leptocarpum Hook. f. et Thoms. (Fam. Papaveraceae). Three of them were identified as protopine, cryptopine and oxyhydrastinine. The fourth is a new alkaloid, named hypecoumine. On the basis of spectroscopic analysis (UV, IR, MS and IHNMR) its structure was elucidated as (1).