郑多楷, 孟佳克, 司伊康, 马顺义, 黄量. 消旋棉酚拆分的研究——Ⅳ.苏(-)或(+)-1-(对硝基苯基)-1,3-二羟基丙胺-2为拆分剂J. 药学学报, 1990, 25(6): 430-434.
引用本文: 郑多楷, 孟佳克, 司伊康, 马顺义, 黄量. 消旋棉酚拆分的研究——Ⅳ.苏(-)或(+)-1-(对硝基苯基)-1,3-二羟基丙胺-2为拆分剂J. 药学学报, 1990, 25(6): 430-434.
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DK Zheng, JK Meng, YK Si, SY Ma , L Huang, . STUDIES ON THE RESOLUTION OF RACEMIC GOSSYPOL Ⅳ. USE OF THREO (-) OR (+)-1-(p-NITROPHENYL)-1,3-DIHYDROXYPROPYLAMINE-2 AS THE RESOLVING AGENTJ. Acta Pharmaceutica Sinica, 1990, 25(6): 430-434.
Citation: DK Zheng, JK Meng, YK Si, SY Ma , L Huang, . STUDIES ON THE RESOLUTION OF RACEMIC GOSSYPOL Ⅳ. USE OF THREO (-) OR (+)-1-(p-NITROPHENYL)-1,3-DIHYDROXYPROPYLAMINE-2 AS THE RESOLVING AGENTJ. Acta Pharmaceutica Sinica, 1990, 25(6): 430-434.
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消旋棉酚拆分的研究——Ⅳ.苏(-)或(+)-1-(对硝基苯基)-1,3-二羟基丙胺-2为拆分剂

STUDIES ON THE RESOLUTION OF RACEMIC GOSSYPOL Ⅳ. USE OF THREO (-) OR (+)-1-(p-NITROPHENYL)-1,3-DIHYDROXYPROPYLAMINE-2 AS THE RESOLVING AGENT

    摘要
  • 摘要: 本文介绍以光学活性苏-1-(对硝基苯基)-1,3-二羟基丙胺-2为拆分剂,与消旋棉酚缩合,用常压柱色谱或溶剂结晶法分离得到两个光学纯的非对映体,然后分别水解得(+)和(-)-棉酚。

     

    Abstract: Threo (-) or (+)-1-(p-nitophenyl )-1, 3-dihydroxy propylamine -2 was found to be a useful resolving agent for racemic gossypol. The optical and chemical stability of the condensate of enantiomeric gossypols with the titled amine and the great difference in the Rf values on TLC and the solubilities in various solvents between the two diastereoisomeric condensates facilitate the separation.Therefore,the pure isomers can be easily obtained by means of chromatography or crystallization.

     

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