大花哥纳香的化学成分

胡正波; 廖时萱; 毛士龙; 朱洪平; 许颂; 梁华清

大花哥纳香的化学成分

STUDIES ON THE CHEMICAL CONSTITUENTS OFGONIOTHALAMUS GRIFFITHII HOOK.F.ET THOMS

摘要

摘要: 目的：研究云南西双版纳大花哥纳香(Goniothalamus griffithii Hook.f.et Thoms)茎皮的化学成分。方法：利用各种色谱技术进行分离纯化，根据理化性质和光谱数据等进行结构鉴定。结果：从大花哥纳香茎皮的乙醇提取物中分离得到5个化合物,其结构分别鉴定为5,7-二羟基双氢黄酮(I)，5,6-2H-6-苯乙烯吡喃-2-酮(II)，(5R,6S,7R,8R)-7-羟基-8-苯基-四氢呋喃骈［3,2-b］-2H-吡喃-2-酮(III)，(6R,7R,8R)-6-(7,8-二羟基苯乙基)-5,6-2H-吡喃-2-酮(IV)，(4S,5R,6S,7S,8R)-6-羟基-7-(α-乙酰氧基苄基)-四氢呋喃骈［3,2-b］呋喃-2-酮(V)。初步药理实验表明,化合物II～V有一定的抗肿瘤活性。结论：化合物V为新化合物,化合物II和III是首次从该植物中分离得到。

Abstract: AIM: To study the chemical composition in the bark of Goniothalamus griffithii Hook.f.et Thoms. METHODS: Various chromatographic techniques and structural elucidation methods were used to separate and purify the constituents. Their physical and chemical properties and spectral data were measued. RESULTS: Five compounds were isolated from the bark of Goniothalamus griffithii. They were identified as: 5,7-dihydroxyflavanone (I); 5,6-2H-6-styryl-2-pyrone (II); (5R,6S,7R,8R)-7-hydroxy-8-phenyl-tetrahydrofuro［3,2-b］pyran-2-one (III); (6R,7R,8R)-6-(7,8-dihydroxyphenylethyl)-5,6-2H-pyran-2-one (IV); (4S,5R,6S,7S,8R)-6-hydroxy-7-(α-acetoxybenzyl)-tetrahydrofuro［3,2-b］furan-2-one (V). CONCLUSION: Compound V is a new compound. Compound II and III were obtained from this plant for the first time. The pharmacological experiments indicated that Sub II～V had the acti-cancer activity.

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