Abstract: The saponin (SSLG) used in this study is the total saponin extracted from the stems and leaves of Panax ginseng C. A. Mey. This paper describes results of the study on the effect of SSLG on several kinds of liver injuries.SSLG was found to shorten pentobarbital sleeping time in normal mice and to induce increase of hepatic microsomal P-450 level 24 h after oral (50 mg/kg) or peritoneal (20 mg/kg) administration. In CCl₄ or thioacetamide intoxicated mice, prior oral administration of SSLG can impede the elevation of SGPT level and decrease the contents of P-450, RNA, and glycogen.In addition, SSLG was also shown to prevent the development of fatty liver and liver cirrhosis because it lowered the contents of hepatic fat and hydroxyproline. Obvious improvement of the histological changes was also observed. For the immunological injury of the liver in mice, SSLG was found to decrease only LDH-5 level, while no inhibitory effect on the elevation of immune complex level in serum and histological changes of the liver was observed. Besides, SSLG was shown to promote secretory function of the liver in eliminating BSP in normal or CCl₄-intoxicated mice. These results indicate that SSLG possesses Protective action on experimental liver injuries.