Ocean is a unique and excellent resource that provides a diverse array of intriguing natural  products.  Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades.  It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields.  This article focused on the research progress of chemistry of marine natural products in recent five years.