糙海参中具有抗真菌活性的三萜皂苷(英文)

Antifungal active triterpene glycosides from sea cucumber Holothuria scabra

摘要:
为了研究糙海参体内的化学成分，寻找结构新颖具有抗真菌活性的三萜皂苷类成分。应用多种色谱分离技术对糙海参体内的化学成分进行分离纯化，根据化合物的理化性质、波谱数据及化学方法鉴定其结构。分离得到3个三萜皂苷化合物，分别为scabraside A (1)、echinoside A (2) 和holothurin A₁ (3)，并对其抗真菌活性进行了研究 (1≤MIC₈₀≤16 μg·mL⁻¹)。化合物1为新的三萜皂苷化合物，化合物2和3为首次从该海参中分离得到，它们均显示显著的抗真菌活性。

Abstract:
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica ge1 chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoside A (2) and holothurin A₁ (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1≤MIC₈₀≤16 μg·mL⁻¹).