陳德崙. 國產鴉膽子化學成分的研究 (一)固定油的成分測定J. 药学学报, 1954, 2(1): 47-56.
引用本文: 陳德崙. 國產鴉膽子化學成分的研究 (一)固定油的成分測定J. 药学学报, 1954, 2(1): 47-56.
Chen Tak-lun. ON THE CHEMICAL CONSTITUENTS OF THE CHINESE DRUG, "YA-TAN-TZE", FRUITS OF BRUCEA JAVANICA (LINN.) MERR. Part Ⅰ. The Chemical Composition of Fixed Oil ConstituentsJ. Acta Pharmaceutica Sinica, 1954, 2(1): 47-56.
Citation: Chen Tak-lun. ON THE CHEMICAL CONSTITUENTS OF THE CHINESE DRUG, "YA-TAN-TZE", FRUITS OF BRUCEA JAVANICA (LINN.) MERR. Part Ⅰ. The Chemical Composition of Fixed Oil ConstituentsJ. Acta Pharmaceutica Sinica, 1954, 2(1): 47-56.

國產鴉膽子化學成分的研究 (一)固定油的成分測定

ON THE CHEMICAL CONSTITUENTS OF THE CHINESE DRUG, "YA-TAN-TZE", FRUITS OF BRUCEA JAVANICA (LINN.) MERR. Part Ⅰ. The Chemical Composition of Fixed Oil Constituents

  • 摘要: 此部分工作是作者於1942年在昆明前中央藥物研究所完成,近閱1950年中華醫學雜誌有于光元及李寶實两氏,又1955年中華耳鼻喉科雜誌有王世勳、陳守毅兩氏相继發表的关於鴉胆子固定油具有醫疗乳头瘤或及外耳道和喉乳頭狀瘤之臨床效能报告,为配合此方面研究與决定有效成分問题的發展,作者謹將此文發表。根據本研究,這植物果實固定油成分中含种類繁複的脂酸類和特異的高碳烃及(石享)類等化合物。這似與近年Grabtree及Patter等氏報導關於有機不飽和酸類抑制瘤腫作用有关,(Cancer Research,2:688,1942;4:688,1944:5:546,1945)頗足为探研鴉膽子油治瘤有效成分的参考。

     

    Abstract: 1. The oil from fruits of Chinese drug,"Ya-tan-tze", Brucea javanica(Linn.) Merr., has been studied, and its physical and chemical constants determined. The composition of fatty acids and unsaponifiable matter were also individually identified. 2. The composition of fatty acids was fractionated by a specially modified method of fractional precipitation with silver nitrate solution, while the unsaturated fatty acids were fractionated with bromo-derivative method. The percentage contents of the various fatty acids present are as follows: (1) Saturated fatty acids: Arachidic acid......66.94% Unknown acid......30.09% Caproic acid......2.96% (2) Unsaturated fatty acids: Oleic acid......99.25% Linolenic acid......0.75% Clupanodonic acid......trace 3. From the unsaponifiable matter fraction, a higher homologue of hydrocarbon was isolated. It is a kind of colourless flake crystal, m.p. 61-63℃, its formula being proposed as C35H72 by molecular weight(Rast method) determination. This hydrocarbon is thus preliminarily proved as an isomer of pentatriacontane, a new constituent in this genus of the plant, although the isolation of another hydrocarbon, hentriacontane, C31He64, from the fruits of Brucea sumatrana Roxb. had been previously reported. Besides the hydrocarbon, a trace of phytosterol was also found in the unsaponifiable matter, its acetylated product, a kind of colourless thin flake crystal, m.p. 104-106℃, admixed with a trace of paraffin wax.

     

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