籍秀娟, 张福荣. 靛玉红类化合物的抗肿瘤作用及构效关系的研究J. 药学学报, 1985, 20(2): 137-139.
引用本文: 籍秀娟, 张福荣. 靛玉红类化合物的抗肿瘤作用及构效关系的研究J. 药学学报, 1985, 20(2): 137-139.
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JI Xiu-Juan, ZHANG Fu-Rong. STUDIES ON ANTINEOPLASTIC ACTION OF INDIRUBIN DERIVATIVES AND ANALOGUES AND THEIR STRUCTUREACTIIVITY RELATIONSHIPSJ. Acta Pharmaceutica Sinica, 1985, 20(2): 137-139.
Citation: JI Xiu-Juan, ZHANG Fu-Rong. STUDIES ON ANTINEOPLASTIC ACTION OF INDIRUBIN DERIVATIVES AND ANALOGUES AND THEIR STRUCTUREACTIIVITY RELATIONSHIPSJ. Acta Pharmaceutica Sinica, 1985, 20(2): 137-139.
shu

靛玉红类化合物的抗肿瘤作用及构效关系的研究

STUDIES ON ANTINEOPLASTIC ACTION OF INDIRUBIN DERIVATIVES AND ANALOGUES AND THEIR STRUCTUREACTIIVITY RELATIONSHIPS

    摘要
  • Abstract: Twenty-four indirubin derivatives or analogues have been subjected to experimental antitumor tests. Preliminary results revealed that 13 compounds showed marked inhibitory action against Walker 256 in rats with a tumor weight inhibition of 2967%. Among them compounds 3,4,12,14 and 22 exhibited higher activity than indirubin, especially compounds 3 and 22. The structure-activity relationship of this series of indirubin derivatives and its analogues is discussed.

     

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