Abstract: AIM　To develop a method for systematic analysis of 47 toxicants and drugs in plasma. METHODS　A new versatile solid-phase extraction/concentrator (SPEC) plus Multi-Modal disc was selected to extract the acidic, neutral and basic drugs by two different eluents, acidic ethyl acetate and basic ethyl acetate. The determinations were programmed by combining retention time, diagnostic ions and library search. Six to eight ions per category were individually selected from the mass spectra of the corresponding drugs and their metabolites. The screening was performed using reconstructed mass chromatograms of selected ions per category. RESULTS　The absolute recoveries of 21 drugs from plasma exceeded 78% with relative standard deviations less than 7% at concentrations of 20 μg*mL^-1 and 5 μg*mL^-1. The developed methods were applied to the detection of acute toxicants with good results. CONCLUSION　These developed methods are simple, sensitive, rapid and reliable.