张秀平, 陈根娣, 戴祖瑞, 马志明. 疟疾防治药物的研究——Ⅻ.2,4-二取代-6-取代氨基喹唑啉衍生物的合成及其抗疟作用J. 药学学报, 1984, 19(10): 792-795.
引用本文: 张秀平, 陈根娣, 戴祖瑞, 马志明. 疟疾防治药物的研究——Ⅻ.2,4-二取代-6-取代氨基喹唑啉衍生物的合成及其抗疟作用J. 药学学报, 1984, 19(10): 792-795.
shu
ZHANG Xiu-Ping, CHEN Gen-Di, DAI Zu-Rui , MA Zhi-Ming, . STUDIES ON ANTIMALARIALS Ⅻ.SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME DERIVATIVES OF 2,4-DISUBSTITUTED-6-SUBSTITUTED AMINO OUINAZOLINESJ. Acta Pharmaceutica Sinica, 1984, 19(10): 792-795.
Citation: ZHANG Xiu-Ping, CHEN Gen-Di, DAI Zu-Rui , MA Zhi-Ming, . STUDIES ON ANTIMALARIALS Ⅻ.SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME DERIVATIVES OF 2,4-DISUBSTITUTED-6-SUBSTITUTED AMINO OUINAZOLINESJ. Acta Pharmaceutica Sinica, 1984, 19(10): 792-795.
shu

疟疾防治药物的研究——Ⅻ.2,4-二取代-6-取代氨基喹唑啉衍生物的合成及其抗疟作用

STUDIES ON ANTIMALARIALS Ⅻ.SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME DERIVATIVES OF 2,4-DISUBSTITUTED-6-SUBSTITUTED AMINO OUINAZOLINES

    摘要
  • Abstract: 2,4-Diamino-, 2-amino-4-hydroxy-and 2,4-dihydroxy-6-substituted amino quinazolines were synthesized and evaluated for their antimalarial activities. Preliminary screening tests conducted on mice infected with Plasmodium berghei showed that most compounds of Ⅱ and Ⅲ were effective in varying degrees in the blood schizonticidal test, with compounds Ⅲ2～4 being as effective as nitroquine. Compounds V were found to have some effects, but compounds of Ⅳ, Ⅵ and Ⅶ were shown to be inactive.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回