大丁草中抗菌活性成分的研究

STUDIES ON ANTIBACTERIAL CONSTITUENTS FROM GERBERA ANANDRIA (L.) SCH. BIP.

摘要: 从菊科植物大丁草Gerbera anandvia(L.)Sch Bip.(Leibnitzia anandria(L.)Nakai)全草中分离出十二种化合物。经化学反应及光谱分析鉴定、确定了其中九个化合物的结构。共中晶Ⅷ(大丁纤维二糖甙,5-methyl-coumarin-4-cellobioside)和晶Ⅸ(大丁龙胆二糖甙,5-methyl-coumarin-4-gentiobioside)为二个新的天然产物。其它七种化合物为大丁双香豆特(Ⅰ)、大丁甙元(Ⅱ)、琥珀酸(Ⅲ)、大丁甙(Ⅴ)、木犀草素7-β-D-葡葡糖甙(Ⅵ)、蒲公英赛醇(Ⅺ)和β-谷甾醇(Ⅻ)。其中晶Ⅰ,Ⅱ,Ⅲ,Ⅷ和Ⅸ显示了不同程度的抗菌活性。

Abstract: Twelve compounds have been isolated from Gerbera anandria(L.) Sch. Bip. Among them, nine were elucidated by chemical correlations and spectralanalysis. They are 3,3'-methenebi (4-hydroxy-5-methyl-coumarin) (Ⅰ), 4-hydroxy-5-methyl-coumarin(Ⅱ), succinic acid(Ⅲ), 5-methyl-coumarin-4-glucoside(Ⅴ), luteolin-7-glucoside(Ⅵ), 5-methyl-coumarin-4-cellobioside(Ⅷ), 5-methyl-coumarin-4-gentiobioside(Ⅸ), taraxerol(Ⅺ) and β-sitosterol(Ⅻ). Both Ⅷ and Ⅸ are new compounds. Ⅰ, Ⅱ, Ⅲ, Ⅷ and Ⅸ showed certain antibacterial activities.