高宏瑾, 岳凤先, 朱任宏. 中国乌头的研究——Ⅹ.关白附子中的新生物碱J. 药学学报, 1966, 13(3): 186-194.
引用本文: 高宏瑾, 岳凤先, 朱任宏. 中国乌头的研究——Ⅹ.关白附子中的新生物碱J. 药学学报, 1966, 13(3): 186-194.
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GAO HONG-GIN YE FENG-HIAN CHU JEN-HUNG, . The Alkaloids of Chinese Drug,Aconitum spp.——Ⅹ.New Alkaloids from Guan-Bai-Fu-Tzu,Aconitum koreanumJ. Acta Pharmaceutica Sinica, 1966, 13(3): 186-194.
Citation: GAO HONG-GIN YE FENG-HIAN CHU JEN-HUNG, . The Alkaloids of Chinese Drug,Aconitum spp.——Ⅹ.New Alkaloids from Guan-Bai-Fu-Tzu,Aconitum koreanumJ. Acta Pharmaceutica Sinica, 1966, 13(3): 186-194.
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中国乌头的研究——Ⅹ.关白附子中的新生物碱

The Alkaloids of Chinese Drug,Aconitum spp.——Ⅹ.New Alkaloids from Guan-Bai-Fu-Tzu,Aconitum koreanum

    摘要
  • 摘要: 从关白附子(Aconitum koreanum R.Raymund)中共分得六种生物碱。其中一种是已知生物碱,卽次乌头碱,另五种为新生物碱,暂称为关附甲素C24H31O6N、乙素C22H29O5N、丙素C22H33O2N、丁素C24H35O3N及戊素C29H_(43)O7N。关附甲素是关附乙素的一乙酸酮。关附甲素、乙素、丙素的示性式分别定为:C19H20(OH)2(CH3COO)2(CH3)(∶N·),C19H20(OH)3(CH3COO)(CH3)(∶N·),C19H23(OH)2(CH3)(N—C2H5)。后二种生物碱因量少尚待研究。

     

    Abstract: Six alkaloids have been isolated from the Chinese drug, Guan-Bai-Fu-Tzu, Aconitum koreanum R.Raymund. One of them was found to be identical with hypaconitine and the other five appeared to be new alkaloids, which are provisionally named as guan-fu base A,B,C,D and E respectively. Physical and chemical data of these new alkaloids are as follows:The guan-fu base A,C24H31O6N, m.p. 198℃, αD22.8+49°(chloroform). Several crystalline salts and derivative were prepared: nitrate, m.p.265℃; hydrochloride,m.p.290℃;hydrobromide,m.p.293℃; perchlorate,m.p.272—273℃; methiodide, m.p. 284.5—285.5℃ and diacetate, m.p. 154.5—155℃. When it was hydrolysed in methanolic potassium hydroxide, an amino alcohol C20H27O4N, m.p.243—244℃ and acetic acid were obtained. On oxidation with acidic permanganate it gave two crystalline products,C22H27O7N, m.p. 204℃ and C23H29O8N·HClO4, m.p. 286℃ (dec.)respectively. It was easily reduced to dihydro compound C24H35O6N, m.p. 200℃, in the presence of Adams platinum catalyst. The guan-fu base B has the formula C22H29O5N, m.p. 204℃, αD26.6+16°(chloroform). The following crystalline salts and derivative were prepared: hydrobromide, m.p.257—258℃;perchlorate,m.p.255—256℃;methiodide,m.p.317—318℃ and triacetate,m.p.154—155℃. Its monoacetate was to be identical with the guan-fu base A. The guan-fu base C has the formula C22H33O2N, m.p. 150℃, αD16.4-21.2°(alcohol).The following crystalline salts and derivative were obtained:nitrate,m.p. 222℃; hydrobtomide,m.p.235℃ and diacetatic hydrochlorate,m.p.222.5—224℃. The guan-fu base D and E have not been obtained yet in crystalline states. However,the nitrate of guan-fu base D,C24H35O3N·HNO3,m.p.210—211℃ and the perchlorate of guan-fu base E, C29H43O7N·HClO4, m.p.272℃ were prepared. The partial formula of guan-fu base A,B and C are expressed as C19H20(0H)2(CH3COO)2(CH3)(:N·),C19H20(OH)3(CH3COO)(CH3)(:N·)and C19H23(OH)2(CH3)(N—C2H3)respectively.

     

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