新腎上腺素能<i>β</i>-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成

陈志豪; 嵇汝运

陈志豪, 嵇汝运. 新腎上腺素能β-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成J. 药学学报, 1965, 12(9): 623-624.

引用本文:

陈志豪, 嵇汝运. 新腎上腺素能β-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成J. 药学学报, 1965, 12(9): 623-624.

CHEN CHI-HAO KYI ZU-YOONG, . THE SYNTHESIS OF A NEW ADRENERGIC BETA-RECEPTORBLOCKING AGENT 6-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)-1,4-BENZODIOXANEJ. Acta Pharmaceutica Sinica, 1965, 12(9): 623-624.

Citation:

CHEN CHI-HAO KYI ZU-YOONG, . THE SYNTHESIS OF A NEW ADRENERGIC BETA-RECEPTORBLOCKING AGENT 6-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)-1,4-BENZODIOXANEJ. Acta Pharmaceutica Sinica, 1965, 12(9): 623-624.

新腎上腺素能β-受体阻断剂6-(2-异丙氨基-1-羟基乙基)-1,4-苯并二氧己环的合成

THE SYNTHESIS OF A NEW ADRENERGIC BETA-RECEPTORBLOCKING AGENT 6-(2-ISOPROPYLAMINO-1-HYDROXYETHYL)-1,4-BENZODIOXANE

CHEN CHI-HAO KYI ZU-YOONG,

摘要

Abstract: Bromination of 6-acetyl-1,4-benzodioxane gave 6-(α-bromoacetyl)-1,4-benzodioxane (IVb), which was condensed with isopropylamine, forming 6-(α-isopropylaminoacetyl)- 1,4-benzodioxane (IVc). The latter compound afforded the desired aminoethanol (III) upon reduction with potassium borohydride.Pharmacological examinations revealed that III was more potent in adrenergic beta-blocking effect, but was less toxic in comparison with pronethalol.

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