赵晶, 张致平, 陈鸿珊, 陈湘红, 张兴权. 黄芩甙元及其苄基衍生物的制备与抗人免疫缺陷病毒实验研究J. 药学学报, 1997, 32(2): 140-143.
引用本文: 赵晶, 张致平, 陈鸿珊, 陈湘红, 张兴权. 黄芩甙元及其苄基衍生物的制备与抗人免疫缺陷病毒实验研究J. 药学学报, 1997, 32(2): 140-143.
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J Zhao, ZP Zhang, HS Chen, XH Chen , XQ Zhang, . PREPARATION AND ANTI-HIV ACTIVITY STUDY OF BAICALIEN AND ITS BENZYLATED DERIVATIVESJ. Acta Pharmaceutica Sinica, 1997, 32(2): 140-143.
Citation: J Zhao, ZP Zhang, HS Chen, XH Chen , XQ Zhang, . PREPARATION AND ANTI-HIV ACTIVITY STUDY OF BAICALIEN AND ITS BENZYLATED DERIVATIVESJ. Acta Pharmaceutica Sinica, 1997, 32(2): 140-143.
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黄芩甙元及其苄基衍生物的制备与抗人免疫缺陷病毒实验研究

PREPARATION AND ANTI-HIV ACTIVITY STUDY OF BAICALIEN AND ITS BENZYLATED DERIVATIVES

    摘要
  • Abstract: Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5,6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5,7-dihydroxyl flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro .

     

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