金刚大化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF CROOMIA JAPONICA MIQ

摘要: 从百部科黄精叶钩吻属植物金刚大(Croomia japonica Miq)的根部分得五个成分,分别为粉蕊黄杨胺A(pachysamine A,Ⅰ)、金刚大啶(croomionidine,Ⅱ)、金刚大碱(croomme,Ⅲ)、脱氢金刚大碱(didehydrocroomine,Ⅳ)和β-谷甾醇。应用波谱(IP,MS,¹HNMR和¹³CNMR等)分析、理化数据测定和化学转化,确定丁它们的结构,其中金刚大啶为新甾体生物碱。

Abstract: A new steroid alkaloid, namely croomionidine (Ⅱ), together with four known compounds pachysamine A (Ⅰ), croomine (Ⅲ), didehydrocroomine (Ⅳ) and β-sitosterol were isolated from the roots of Croomia japonica Miq.. Their structures were identified by IR, MS, ¹H NMR, ¹³C NMR and chemical conversion.