间硝苯啶和硝苯啶对离体大鼠心脏缺血再灌注的保护作用

PROTECTIVE EFFECTS OF m-NIFEDIPINE AND NIFEDIPINE IN ISOLATED ISCHEMIC-REPERFUSED RAT HEARTS

摘要: 用离体大鼠心脏缺血再灌注模型,观察间硝苯啶和硝苯啶对左心室顺应性及收缩性能的保护作用。缺血30min复灌10min,左心室顺应性和增长压显著降低,左心室僵硬度常数显著增加(P<0.01)。预先ip间硝苯啶(m-Nif)或硝苯啶(Nil)60μg/kg bid×2d,离体灌注时,灌流给予0.5μmol/L m-Nif或Nif,20min可防止缺血再灌注后左心室顺应性、增长压和僵硬度常数的改变。m-Nif和Nif在作用强度上无显著差异。

Abstract: The protective effects of m-nifedipine (m-Nif) and nifedipine (Nif) were studied in isolated rat hearts subjected global ischemia and reperfusion. After global ischemia for 30 min followed by reperfusion for 10 min, left ventricular (LV) compliance and developed pressure (DP) were severely declined, LV stiffness constant was significantly increased (P<0. 01). Previous treatment with m-Nif or Nif prevented changes of LV compliance, stiffness constant and DP caused by ischemia and reperfusion. No marked difference in potency between m-Nif and Nif was observed.