卢玉华, 姬政, 祁建新, 杜灿屏, 陈荣昌, 吴树春. 木犀草素及山奈酚的全合成J. 药学学报, 1980, 15(8): 477-481.
引用本文: 卢玉华, 姬政, 祁建新, 杜灿屏, 陈荣昌, 吴树春. 木犀草素及山奈酚的全合成J. 药学学报, 1980, 15(8): 477-481.
Lu Yuhua, Ji Zheng , Qi Jianxin, . SYNTHESIS OF LUTEOLIN AND KAEMPFEROLJ. Acta Pharmaceutica Sinica, 1980, 15(8): 477-481.
Citation: Lu Yuhua, Ji Zheng , Qi Jianxin, . SYNTHESIS OF LUTEOLIN AND KAEMPFEROLJ. Acta Pharmaceutica Sinica, 1980, 15(8): 477-481.

木犀草素及山奈酚的全合成

SYNTHESIS OF LUTEOLIN AND KAEMPFEROL

  • 摘要: 本文报道了黄酮类化合物木犀草素(祛痰新药)和山奈酚的全合成,改进了合成山奈酚的最后两步反应,即化合物Ⅶ的Algar-Flynn-Oymada氧化反应及化合物Ⅸ的脱甲基反应。以间苯三酚为原料合成木犀草素总收率为3~5%,而合成山奈酚的总收率为10~17%。

     

    Abstract: The synthesis of flavones luteolin and kaempferol is describid. In the preparation of the latter compound, the last two steps, Algar-Oyamada oxidation of Ⅶ and demethylation of Ⅸ have been improved. The overall yields of luteolin, and kaempferol, using phloro-glucinol as the starting material, are 3~5% and 10~17% respectively.

     

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