川东獐牙菜水溶性化学成分

Water-soluble chemical constituents of Swertia davidi Franch.

摘要: 目的研究川东獐牙菜(Swertia davidi Franch)活性成分。方法利用Sephadex LH-20,DA-201大孔吸附树脂等多种色谱技术分离化学成分,UV,IR,MS,¹HNMR,¹³CNMR及2D-NMR等波谱技术鉴定化合物的结构。结果得到4个化合物,分别是8-O-β-D-吡喃葡糖基-1,3,5-三羟基酮(I),5-O-β-D-吡喃葡糖基-1,8-二羟基-3-甲氧基酮(II),5-O-β-D-吡喃葡糖基-1,3,8-三羟基酮(III)和獐牙菜苦苷(IV)。结论III为新化合物,I,II,IV为首次从该植物中分离得到。

Abstract: AimTo study the active constituents of Swertia davidi Franch. MethodsColumn chromatographies on silica gel, Sephadex LH-20 and Diaion-201 et al. were used to isolate and purify the chemical components. Their structures were identified by UV, IR, MS, NMR and 2D-NMR. ResultsThese compounds were elucidated as 8-O-β-D-glucopyranosyl-1,3,5-trihydroxyxanthone (I), 5-O-β-D-glucopyranosyl-1,8-dihydroxy-3-methoxyxanthone (II), 5-O-β-D-glucopyranosyl-1,3,8-trihydroxyxanthone (III) and Swertamarin (IV). ConclusionCompound III is a new xanthone glucoside. The other compounds were isolated from this plant for the first time.