邱丰和, 刘力, 罗毅, 刘峰, 卢涌泉. 固相萃取GC-FID和GC-MS分析血浆中碱性药物J. 药学学报, 1996, 31(4): 296-299.
引用本文: 邱丰和, 刘力, 罗毅, 刘峰, 卢涌泉. 固相萃取GC-FID和GC-MS分析血浆中碱性药物J. 药学学报, 1996, 31(4): 296-299.
shu
FH Qiu, L Liu, Y Luo, F Liu, , YQ Lu. SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MSJ. Acta Pharmaceutica Sinica, 1996, 31(4): 296-299.
Citation: FH Qiu, L Liu, Y Luo, F Liu, , YQ Lu. SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MSJ. Acta Pharmaceutica Sinica, 1996, 31(4): 296-299.
shu

固相萃取GC-FID和GC-MS分析血浆中碱性药物

SYSTEMATIC ANALYSIS OF BASIC DRUGS IN PLASMA USING X-5 SOLID-PHASE EXTRACTION GC-FID AND GC-MS

    摘要
  • 摘要: 报道了用X-5固相萃取分离、毛细管GC-FID和GC-MS定性定量分析人血浆中34种碱性药物的方法。在优化的提取条件下,大部分药物的最低检测浓度在0.5～2.0μg·ml-1之间,线性范围、定量精密度等满足临床中毒分析的要求。

     

    Abstract: A systematic determination method for 34 hasic drugs in human plasma isdescribed. Drugs were extracted from plasma at pH 10 using X-5 resin as adsorbent,then identifiedand quantitated by capillary GC-FID and GC-MS.The detection limits for most drugs are in the rangeof0.5～2.0μg·ml-1.Precision and linearity of the method are satisfactory for clinical toxicologicalapplications.

     

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