曾苏, 章立, 刘志强. RP-HPLC手性流动相添加剂法分析尿中氧氟沙星对映体J. 药学学报, 1994, 29(3): 223-227.
引用本文: 曾苏, 章立, 刘志强. RP-HPLC手性流动相添加剂法分析尿中氧氟沙星对映体J. 药学学报, 1994, 29(3): 223-227.
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S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
Citation: S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
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RP-HPLC手性流动相添加剂法分析尿中氧氟沙星对映体

QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVE

    摘要
  • 摘要: 以L-苯丙氨酸为配合剂,Cu2+为配合离子,建立了一种简便的手性配合交换RP-HPLC拆分氧氟沙星对映体的方法,该法已用于人尿中氧氟沙星对映异构体的分析。

     

    Abstract: The method for determination of S-(-)and R- (+)- ofloxacim(OFLX)in humanutine by RP-HPLC with a chiral mobile phase additive is described.L-phenylalanine was used as thechiral additive,Cu2+ as the ligand ion and fluorescence for detection,This chiral ligand exchangechromatography has been applied to reveal the enantioselective disposition of ofloxacin in humanvolunteers.

     

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