2-取代苯基-5-(3′-吲哚基)-唑衍生物的合成及其抗氧化活性

Synthesis and antioxidative activity of 2-substituted phenyl-5-(3′-indolyl)-oxazole derivatives

摘要: 目的合成5-(3′-吲哚基)-唑衍生物并研究其抗氧化活性。方法以色氨酸为原料,与取代的苯甲酸在DCC催化下脱水缩合得到酰胺,再通过DDQ苄位氧化和分子内环合生成5-(3′-吲哚基)-唑。用DPPH体外抗氧化模型测定化合物的抗氧化活性。结果合成了11个2-取代苯基-5-(3′-吲哚基)-唑衍生物,其中化合物21和22的活性比维生素E强约3～4倍;化合物29的活性与维生素E相近。结论合成的目标化合物中有3个化合物有较好的抗氧化活性,有可能开发成为良好的抗氧化剂。

Abstract: AimTo study the synthesis of 5-(3′-indolyl)-oxazoles and their antioxidative activity. MethodsThe amides were prepared from tryptophan and different acid derivatives by the catalytic dehydration of dicyclohexyl carbodiimide (DCC). The characteristic heterocyclic ring system of 5-(3′-indolyl)-oxazoles was constructed by oxidative cyclization of amide, using dicholorodicyanoquinone (DDQ). Their antioxidative activity in vitro was tested using DPPH system. ResultsEleven 2-substituted phenyl-5-(3′-indolyl)-oxazoles were prepared, the compounds 21 and 22 have shown antioxidative activity 3-4 times stronger than that of Vit E, and the compound 29 showed antioxidative activity almost as same as Vit E. ConclusionThree 5-(3′-indoyl)-oxazole compounds synthesized showed potent antioxidative effect and they would be a good antioxidants.