雷公藤化学成分的研究  Ⅲ.两种新二萜内酯——雷酚内酯甲醚和雷酚新内酯的分离及结构

STUDIES ON THE CHEMICAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII HOOK.F. Ⅲ. THE ISOLATION AND STRUCTURE OF TWO NEW DITERPENOID-LACTONES, TRIPTOPHENOLIDE METHYL ETHER AND NEOTRIPTOPHENOLIDE

摘要: 从福建产雷公藤(Tripterygium wilfordii Hook.f.)的根皮中分离到三种二萜内酯。(1)雷酚内酯(triptophenolide),C₂₀H₂₄O₃,熔点232～233℃。(2)雷酚内酯甲醚(triptophenolide methyl ether),C₂₁H₂₆O₃,熔点152～154℃。(3)雷酚新内酯(neotriptophenolide),C₂₁H₂₆O₄,熔点189～191℃。根据理化性质及UV、IR、¹HNMR、¹³CNMR、MS等光谱数据,推测化学结构分别为Ⅴ、Ⅵ及Ⅶ。Ⅵ与Ⅶ是二种新的二萜内酯化合物。

Abstract: In a previous paper (1) the isolation of triptolide, tripdiolide and triptonolide from Tripterygium wilfordii Hook. f. was reported. This paper reports the isolation of three other diterpenoid-lactones: (1) triptophenolide, C₂₀H₂₄O₃, mp 232～233℃; (2) triptophenolide methyl ether, C₂₁H₂₆O₃, mp 152～154℃, and (3) neotriptophenolide, C₂₁H₂₆O₄, mp 189～191℃. Their structures are assigned as Ⅴ, Ⅵ and Ⅶ, respectively, by spectroscopic analysis (UV, IR, MS, ¹HNMR and ¹³CNMR) and preparation of their derivatives. It has beert shown that Ⅵ and Ⅶ are new diterpenoid compounds.