雪胆甲素甙的化学结构

THE STRUCTURE OF CUCURBITACIN Ⅱ GLYCOSIDE

摘要: 从葫芦科雪胆属园果雪胆的块根中分离到一种新的苦味质——雪胆甲素甙,分子式C₃₈H₆₀O₁₃,熔点154.2～158.2℃,α_d⁷+44°,通过水解和光谱分析证实雪胆甲素甙为19-失碳-9β-甲基-10α-2β,3α,16α,20,25-五羟基-△⁵-羊毛甾烯-11,20-双酮-25,-乙酸酯·2-O-β-D-吡喃葡萄糖甙(Ⅱ)。

Abstract: A new bitter principle, Cucurbitacin Ⅱ glycoside, C₃₈ H₆₀ O₁₃, mp 154.2～158.2℃, α_d⁷+44°, has been isolated from Hemsleya amabilis Diels. On the basis of spectroscopic ¹H NMR and ¹³C NMR, acid hydrolysis or enzyme hydrolysis, the structure was. found to be 2-O-β-D-glucopyranosyl cucurbitacin.