Abstract: AimTo study the pharmacokinetics of β-asarone in rats. MethodsThe concentration of β-asarone in serum and organs were measured by HPLC after ig administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system. ResultsThe pharmacokinetics of β-asarone can be described as first order process of one-compartment model. In the serum, T_1/2 , T_peak and _Cmax were 54 min, 12 min and 3.19 mg·L^-1, respectively. The procedure in the organs was similar to that in serum. ConclusionThe absorption, distribution and elimination of β-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of β-asarone.