Abstract: With an attempte to search for potent nonsteroidal antiinflammatory drugs with less side-effects,twenty Six derivatives of 4-hydroxy-3-aminomethyldiphenyl and 4(2)-cyclohexyl,-2(4)-aminomethylphenol were prepared by Mannich reaction. Nineteen of the compounds were tested in rats. Some of these compounds showed significant antiinflammatory and antipyretic-analgesic activities. Antiimplanration test was also carried out on twenty of the compounds, but none was found active.