杜建业, 臧鳳和. 络合滴定法在生物碱含量测定上的应用Ⅰ.离子交换-络合滴定法测定生物碱盐类J. 药学学报, 1963, 10(1): 10-10.
引用本文: 杜建业, 臧鳳和. 络合滴定法在生物碱含量测定上的应用Ⅰ.离子交换-络合滴定法测定生物碱盐类J. 药学学报, 1963, 10(1): 10-10.
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Tu CHIEN-YEH AND TSANG FENG-HO, . COMPLEXOMETRIC TITRATION IN THE DETERMINATION OF ALKALOIDS Ⅰ. THE DETERMINATION OF ALKALOID SALTS BY CATION-EXCHANGE FOLLOWED BY COMPLEXOMETRIC TITRATIONJ. Acta Pharmaceutica Sinica, 1963, 10(1): 10-10.
Citation: Tu CHIEN-YEH AND TSANG FENG-HO, . COMPLEXOMETRIC TITRATION IN THE DETERMINATION OF ALKALOIDS Ⅰ. THE DETERMINATION OF ALKALOID SALTS BY CATION-EXCHANGE FOLLOWED BY COMPLEXOMETRIC TITRATIONJ. Acta Pharmaceutica Sinica, 1963, 10(1): 10-10.
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络合滴定法在生物碱含量测定上的应用Ⅰ.离子交换-络合滴定法测定生物碱盐类

COMPLEXOMETRIC TITRATION IN THE DETERMINATION OF ALKALOIDS Ⅰ. THE DETERMINATION OF ALKALOID SALTS BY CATION-EXCHANGE FOLLOWED BY COMPLEXOMETRIC TITRATION

    摘要
  • 摘要: 本文介绍了一种测定生物碱的方法——离子交换-络合滴定法,它系利用铜型阳离子交换树脂与生物碱盐类作用,交换出的铜离子再以紫脲酸铵作指示剂用EDTA滴定。本法曾用于硫酸阿托品、硫酸士的宁、硫酸奎宁、盐酸麻黄碱、盐酸普鲁卡因、盐酸硫胺、盐酸吡多辛、盐酸金霉素等八种药物的测定,结果良好;在20毫克时误差在±0.5%以内,10毫克时不超过2%,而且每次测定费时不过20分钟。

     

    Abstract: The determination is carried out by passing a solution of an alkaloid salt through a 0.5×16cm column of cation-exchange resin in the Cu-form. The Cu++ liberated is washed out with 40ml of H2O and titrated with 0.005 or 0.0025 M EDTA·2Na using murexide as indicator. For 10—20mg samples of the hydrochlorides of ephedrine, procaine, thiamine, pyridoxine, aureomycin, and the sulfates of atropine, strychnine, and quinine, the error is 2—0.5%.

     

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