张银娣, 沈建平, 宋键, 王幼林, 邵亚男, 李传富, 周素华, 李一凡, 李德兴. 黄芪皂苷甲对血浆cAMP及再生肝DNA合成的影响J. 药学学报, 1984, 19(8): 619-621.
引用本文: 张银娣, 沈建平, 宋键, 王幼林, 邵亚男, 李传富, 周素华, 李一凡, 李德兴. 黄芪皂苷甲对血浆cAMP及再生肝DNA合成的影响J. 药学学报, 1984, 19(8): 619-621.
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ZHANG Yin-Di, SHEN Jian-Ping, SONG Jian, WANG You-Lin, SHAO Ya-Nan, LI Chuan-Fu, ZHOU Su-Hua, LI Yi-Fan, , LI De-Xing. EFFECTS OF ASTRAGALUS SAPONIN 1 ON cAMP AND cGMP LEVEL IN PLASMA AND DNA SYNTHESIS IN REGENERATING LIVERJ. Acta Pharmaceutica Sinica, 1984, 19(8): 619-621.
Citation: ZHANG Yin-Di, SHEN Jian-Ping, SONG Jian, WANG You-Lin, SHAO Ya-Nan, LI Chuan-Fu, ZHOU Su-Hua, LI Yi-Fan, , LI De-Xing. EFFECTS OF ASTRAGALUS SAPONIN 1 ON cAMP AND cGMP LEVEL IN PLASMA AND DNA SYNTHESIS IN REGENERATING LIVERJ. Acta Pharmaceutica Sinica, 1984, 19(8): 619-621.
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黄芪皂苷甲对血浆cAMP及再生肝DNA合成的影响

EFFECTS OF ASTRAGALUS SAPONIN 1 ON cAMP AND cGMP LEVEL IN PLASMA AND DNA SYNTHESIS IN REGENERATING LIVER

    摘要
  • Abstract: Astragalus saponin 1, one of the components isolated from Astragalus membranaceus Bge was found to induce accumulation of cAMP in rabbit plasma at the ip dose of 10mg/kg. The increase of cAMP started at 30 rain and reached maximum in 0.5～4h after a single injection. The effect of the component on DNA biosynthesis in partially hepatectomized mice seemed to be significant. The component was also shown to enhance the incorporation of 3H TdR into the regenerating liver in mice.

     

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