刘锋, 刘荫棠, 冯翠玲, 罗毅. 血、尿中安眠酮及其代谢物的测定J. 药学学报, 1994, 29(8): 610-616.
引用本文: 刘锋, 刘荫棠, 冯翠玲, 罗毅. 血、尿中安眠酮及其代谢物的测定J. 药学学报, 1994, 29(8): 610-616.
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F Liu, YT Liu, CL Feng , Y Luo, . DETERMINATION OF METHAQUALONE AND ITS METABOLITES IN URINE AND BLOOD BY UV,GC/FID AND GC/MSJ. Acta Pharmaceutica Sinica, 1994, 29(8): 610-616.
Citation: F Liu, YT Liu, CL Feng , Y Luo, . DETERMINATION OF METHAQUALONE AND ITS METABOLITES IN URINE AND BLOOD BY UV,GC/FID AND GC/MSJ. Acta Pharmaceutica Sinica, 1994, 29(8): 610-616.
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血、尿中安眠酮及其代谢物的测定

DETERMINATION OF METHAQUALONE AND ITS METABOLITES IN URINE AND BLOOD BY UV,GC/FID AND GC/MS

    摘要
  • 摘要: 通过一例安眠酮中毒病人血、尿中安眠酮及其代谢物的测定,描述了用紫外光谱(uv)、气相色谱(GC)和气相色谱质谱(GC/MS)法测定安眠酮及其代谢物的系统分析方法。样品的提取净化采用液一液萃取和固相萃取两种方法,都得到了很好的结果。紫外光谱用于测定血、尿中安眠酮和其代谢物的总量;气相色谱用于测定血、尿中安眠酮原药的含量;气相色谱质谱则用于鉴定血、尿中的安眠酮及其代谢物。除安眠酮外,血、尿中共检出10种安眠酮代谢物,其中包括两种乙酰化代谢物。此法还为临床救治提供指导。

     

    Abstract: A systematic procedure for the determination of methaqualone and its metabolitesin blood and urine by UV spectrophotometry ,GC and GC/ MS was developed.Urine and bloodsamples were from a suicidal patient who ingested 18 tablets of methaqualone. Both solid phase andliquid-liquid extractions were used in the extraction and clean-up of the samples.The total amount ofmethaqualone and its metabolites was measured by UV spectrophotometry.The amount of parentmethaquaione was quantitated by GC/FID,Methaqualone and its 10 metabolites including two acetylmetabolites were found in urine and bloed。 This procedure is useful for monitoring drugs in emergencytreatment.

     

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