3′(5α-3β,17β-双羟基-雄甾烷-17α)-丙酸内酯(Ⅴ)的微生物转化——螺旋内酯甾(Ⅱ)的合成
MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ)
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摘要: 3′-(5α-3β,17β-双羟基-雄甾烷-17α)-丙酸内酯(Ⅴ)经诺卡氏菌(Nocardia sp.)转化获得6个化合物(Ⅱ和Ⅵ～Ⅹ),其中螺旋内酯甾(Ⅱ)为其主要产物(～50%)。Ⅷ～Ⅹ是尚未被鉴定的羟基化合物。化合物(Ⅴ)用诺卡氏菌在氮源贫乏的培养基中转化主要生成△4-3-酮化合物,而在氮源丰富的培养基中转化则主要为△1,4-3-酮的产物。Abstract: Incubation of 3'-(5α, 3β, 17β-dihydroxy-androstane-17α)-Propiolactone (Ⅴ) with Nocardia sp. afforded 6 compounds (Ⅱ and Ⅵ～Ⅹ), among which spirolactone (Ⅱ) was. the major product (～50%). Ⅷ～Ⅹ were unidentified hydroxy compounds. The △4-3-keto compound (Ⅱ) is the main product when the medium is poor in nitrogen.
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