Abstract: Ten analogs of baogongteng A, the natural cholinergic tropane alkaloid isolated from Erycibe obtusifolia Benth, were designed and synthesized. The tropane skeleton was kept unchanged, while the substituting groups on N and C₃ were modified. In myotic experiments in rabbits 3-paramethyl benzoyloxy- 6-acetoxy nortropane (4), 3-propionyloxy- 6-acetoxy nortropane (5), and 3-isobutyryloxy-6-acetoxy nortropane(6) showed cholinergic activities.