毛叶香茶菜抗癌成分的研究——Ⅰ.毛叶香茶菜素A和B的结构

STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND B

摘要: 自毛叶香茶菜Rabdosia japonica(Burm.f)Hara的干叶中分离出四个二萜化合物,其中两个是新的二萜,命名为毛叶香茶菜素A和B。通过光谱分析和化学反应转变成已知化合物epinodosin 6和isodonal 8确定了毛叶香茶菜素A和B的结构分别为3和7。初步的抗癌试验表明,3和7都具有明显细胞毒作用。其它两个二萜成分证明为enmenol 4和epinodosinol 5。

Abstract: Four diterpenoids were isolated from the dried leaves of Rabdosia japonica (Burm.f) Hara. Two new diterpenoids were named as rabdosin A and B. Spectroscopic investigation and chemical conversion into epinodosin(6) and isodonal(8) established the structures of rabdosin A and B as(3) and(7)respectively. Antitumor activity has been tested preliminarily, both (3) and (7) showed significant cytotoxicity. The other two diterpenoids were shown to be identical with the known enmenol (4) and peinodosinol(5).