Abstract: Twenty-six compounds of halogen, nitro, alkoxy, amino, and acetamino substituted cinnamamides have been synthesized. The coupling constants of the NMR spectra of the protons on the double bond of these compounds demonstrate that their configurations are all trans. The anticonvulsant activity (MES) of 3-chloro and 2,4-dichloro substituted cinnamamides were found to be more potent than other members of the series studied. The anticonvulsant activities of electron donating amino substituted cinnamoyl piperidines are cgmparable with those of the chloro compounds.