6-连氮和6<i>α</i>-甲氧基-6<i>β</i>-取代腙青霉素的合成及抗菌活性

钟伊利; 李润荪; 雷兴翰

钟伊利, 李润荪, 雷兴翰. 6-连氮和6α-甲氧基-6β-取代腙青霉素的合成及抗菌活性J. 药学学报, 1988, 23(11): 820-824.

引用本文:

钟伊利, 李润荪, 雷兴翰. 6-连氮和6α-甲氧基-6β-取代腙青霉素的合成及抗菌活性J. 药学学报, 1988, 23(11): 820-824.

YL Zhong, RS Li , XH Lei, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6-AZINO- AND 6α-METHOXY-6β-HYDRAZONO-PENICILLINSJ. Acta Pharmaceutica Sinica, 1988, 23(11): 820-824.

Citation:

YL Zhong, RS Li , XH Lei, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6-AZINO- AND 6α-METHOXY-6β-HYDRAZONO-PENICILLINSJ. Acta Pharmaceutica Sinica, 1988, 23(11): 820-824.

6-连氮和6α-甲氧基-6β-取代腙青霉素的合成及抗菌活性

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 6-AZINO- AND 6α-METHOXY-6β-HYDRAZONO-PENICILLINS

YL Zhong,
RS Li , XH Lei,

摘要

摘要: 本文报道新颖的6-连氮和6α-甲氧基-6β-取代腙青霉素的合成及引入6α-甲氧基的新方法。这类化合物对一些阴性菌和阳性菌有中等活力,且引入6α-甲氧基之后对细菌的抑制作用增强。

Abstract: 6-Azino-and 6α-methoxy-6β-hydrazono-penicillins were synthesized for the first time and a new general method for the introduction of the methoxy group into the 6α-position of penicillin was disclosed. Some of them show moderate antibacterial activity.

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