碳环核苷类化合物的合成

乔雷, 马灵台, 闵吉梅, 张礼和. 碳环核苷类化合物的合成J. 药学学报, 1991, 26(6): 420-425.

引用本文:

乔雷, 马灵台, 闵吉梅, 张礼和. 碳环核苷类化合物的合成J. 药学学报, 1991, 26(6): 420-425.

L Qiao, LT Ma, JM Min , LH Zhang, . SYNTHESIS OF ANALOGUES OF CARBOCYCLIC NUCLEOSIDEJ. Acta Pharmaceutica Sinica, 1991, 26(6): 420-425.

Citation:

L Qiao, LT Ma, JM Min , LH Zhang, . SYNTHESIS OF ANALOGUES OF CARBOCYCLIC NUCLEOSIDEJ. Acta Pharmaceutica Sinica, 1991, 26(6): 420-425.

SYNTHESIS OF ANALOGUES OF CARBOCYCLIC NUCLEOSIDE

摘要: 通过氯代环戊烯和相应的嘧啶碱基缩合,再环氧化和开环得到了5′-去羟甲基碳环核苷类似物。所合成化合物经体外L₁₂₁₀和肝癌细胞筛选,并用2215细胞株进行抗乙肝病毒筛选,均未发现有意义的活性。

Abstract: The derivatives of 5'-dehydroxymethyl carbocyclic nucleoside were synthesized by condensation of cyclopentenyl chloride and corresponding pyrimidines followed by epoxidation and substitution. All compounds were screened for anticancer and antiviral activities and no activity was found.

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