中药玉竹有效成分研究

林厚文; 韩公羽; 廖时萱

中药玉竹有效成分研究

STUDIES ON THE ACTIVE CONSTlTUENTS OF THE CHlNESE TRADlTIONAL M EDlCINE POLYGONATUM ODORATUM (MILL．)DRUCE

HW Lin．GY Han,
SX Liao,

摘要

摘要: 自江苏海门产百合科植物玉竹Polygonatum odoratum(Mill.)Druce根茎的乙醇提取物中分得六个单体化合物,根据化学性质和光谱解析,鉴定其化学结构分别为β-谷甾醇(S-A)),β-谷甾醇-3-O-β-D-吡喃葡萄糖甙(S-B),25(R,S)螺甾-5-烯-3β-醇-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃木糖基-(1→3)-β-D-吡喃葡萄糖基(1→4)-β-吡喃半乳糖甙(POD-I),25(R)螺甾-5-烯-3β,14a-二醇-3-0-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃木糖基-(1→3)-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖甙(POD-II),25(R,S)螺甾-5-烯-3β,14a-二醇-3-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基-(1→3)-β-D-吡喃葡萄糖基(1→4)-β-D-吡喃半乳糖甙(POD-III)和25(R,S)螺甾-5-烯-3β-醇-3-O-β-D-吡喃葡萄糖基-(1-2)-β-D-吡喃葡萄糖基-(1→3)-β-D-吡喃哺葡萄糖基(1→4)-β-D-吡喃半乳糖甙(POD-IV)。POD-II为首次分离得到的25(R)构型的纯品,POD-III和POD-IV为首次从玉竹中得到。经初步药理实验显示,POD-II有诱生集落刺激因子(CSF)的作用,POD-III能协同ConA和Lps对淋巴细胞转化有促进作用。

Abstract: From the ethanol extract of the Chinese traditional medicine ,rhizomes of Polygona-tum odoratum,a new steroidal saponin POD-Ⅱ together with β-sitosterol and its glucoside ,and threeknown saponins were isolated.On the basis of chemical evidence and spectral analysis(UV ,IR,EI-MS,¹HNMR and1 ³CNMR),the structure of POD-Ⅱ was elucidated as 3-O-β-D-glucopyranosyL-(1→2)- β-D- xylopyranosyl-( 1→3)- β-D- glucopyranosyl-(1→4)-galactopyranosyl-25(R)- spirost-5- en-3β,14α-diol.Preliminary pharmacologicaI tests showed that POD-Ⅱ could induce the colony stimu-lating factor(CSF)in mouse serum; and POD-Ⅲ,at the concentration of 0.1μg·mL^-1 was shown tosynergize the suboptimal and optimal concentration of Con A and lipopolysaccharide to stimulate lymp-hocytes proliferation.

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