钟文远, 胡智兴, 陈顺方, 纪舒昱, 周轶平, 李玛琳. ［Ln(Phen)2(5-Fu)3(NO3)］(NO3)2的合成、表征及体外抗肿瘤活性研究J. 药学学报, 2005, 40(11): 997-1000.
引用本文: 钟文远, 胡智兴, 陈顺方, 纪舒昱, 周轶平, 李玛琳. ［Ln(Phen)2(5-Fu)3(NO3)］(NO3)2的合成、表征及体外抗肿瘤活性研究J. 药学学报, 2005, 40(11): 997-1000.
shu
ZHONG Wen-yuan, HU Zhi-xing, CHEN Shun-fang, JI Shu-yu, ZHOU Yi-ping, LI Ma-lin. Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln［(Phen)2(5-Fu)3(NO3)］(NO3)2J. Acta Pharmaceutica Sinica, 2005, 40(11): 997-1000.
Citation: ZHONG Wen-yuan, HU Zhi-xing, CHEN Shun-fang, JI Shu-yu, ZHOU Yi-ping, LI Ma-lin. Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln［(Phen)2(5-Fu)3(NO3)］(NO3)2J. Acta Pharmaceutica Sinica, 2005, 40(11): 997-1000.
shu

［Ln(Phen)2(5-Fu)3(NO3)］(NO3)2的合成、表征及体外抗肿瘤活性研究

Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln［(Phen)2(5-Fu)3(NO3)］(NO3)2

    摘要
  • 摘要: 目的研究稀土元素的生物化学作用和无机、有机抗肿瘤药物的协同作用。方法用稀土硝酸盐、邻菲罗啉(Phen)、氟尿嘧啶(5-Fu)合成了7种稀土配合物。用MTT,SRB法进行体外抗肿瘤活性研究。结果经过元素分析、摩尔电导率测定、差热分析、红外光谱测定和核磁共振谱测定，初步确定配合物化学式为［Ln(Phen)2(5-Fu)3(NO3)］(NO3)2。配合物对K562(人粒细胞白血病细胞株)、CA(人肝癌细胞株)、SGC-7901(人胃癌细胞株)、HCT(人结肠癌细胞株)、GLC-82(人肺癌细胞株)和CNE(人鼻咽癌细胞株)增殖有很强的抑制作用。结论配合物产生了抗肿瘤协同作用。

     

    Abstract: AimTo study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs. MethodsA series of rare earth complexes were synthesized with Ln(NO3)3·6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods. ResultsThe formula of complex Ln［(Phen)2(5-Fu)3(NO3)］(NO3)2 (Ln=Y, La, Ce, Sm, Gd, Dy, Er; Phen=1,10-phenanthroline; 5-Fu=fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro. ConclusionThe complex might have anti-tumor cooperation action.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回