杨迎, 张均田, 石成璋, 屈志炜, 刘雨. 人参皂甙Rb1和Rg1促智作用机制的探讨──对小鼠脑神经发育的影响J. 药学学报, 1994, 29(4): 241-245.
引用本文: 杨迎, 张均田, 石成璋, 屈志炜, 刘雨. 人参皂甙Rb1和Rg1促智作用机制的探讨──对小鼠脑神经发育的影响J. 药学学报, 1994, 29(4): 241-245.
Y Ying, J T Zhang, C Z Shi, Z W Qu , YLiu, . STUDY ON THE NOOTROPIC MECHANISM OF GINSENOSIDE Rb1AND Rgl —— INFLUENCE ON MOUSE BRAIN DEVELOPMENTJ. Acta Pharmaceutica Sinica, 1994, 29(4): 241-245.
Citation: Y Ying, J T Zhang, C Z Shi, Z W Qu , YLiu, . STUDY ON THE NOOTROPIC MECHANISM OF GINSENOSIDE Rb1AND Rgl —— INFLUENCE ON MOUSE BRAIN DEVELOPMENTJ. Acta Pharmaceutica Sinica, 1994, 29(4): 241-245.

人参皂甙Rb1和Rg1促智作用机制的探讨──对小鼠脑神经发育的影响

STUDY ON THE NOOTROPIC MECHANISM OF GINSENOSIDE Rb1AND Rgl —— INFLUENCE ON MOUSE BRAIN DEVELOPMENT

  • 摘要: 以0.125,0.25mg·ml-1的人参皂甙Rb1和Rg1水溶液作为刚断乳小鼠唯一的饮用水,喂养4周至新成年。对照组动物给自来水,人参皂甙摄入量为Rb128.6及56.1mg·kg-1;Rg127.4及53.9mg·kg-1。结果发现Rb1和Rg1均可促进幼鼠身体发育和脑神经发育,并易化小鼠成年后跳台法和避暗法记忆获得过程。用突触定量技术,首次发现较长期给予Rb1和Rg1可明显增加小鼠海马CA3区椎体细胞上层的突触数目(P<0.01),从而揭示了人参皂甙促进动物学习记忆的组织形态学基础。

     

    Abstract: Weaning mice were supplied drinking water containing Rb1 or Rg1 0.125 or 0.25mg·mL-1 for 4 weeks.Rb1(28.6 and 56.1 mg·kg-1)and Rg1(27.4 and 53.9 mg·kg-1)were found to accelerate young mice body and brain development as well as facilitate memoryacquisition in step down and step through avoidance response tests. With the technique of quantitativemeasurement synapses ,we found for the first time that Rb1 and Rg1 administration for 4 weeks canincrease synapse number in the hippocampal CA3 region of mice. This is the morphological basis forexplaining Rb1 and Rg1 induced facilitation of learning and memory.

     

/

返回文章
返回