Abstract: Three compounds(N₁,N₂ and N₃)had been isolated from Coniselinum vaginatum Thell and were shown to have strong hepatoprotective activities.Coniselin(N4)is a new naturalcompound isolated from the alcoholic extracts of C.vaginatum Thell.To confirm its structure andprepare enough sample for investigating its pharmacological activities , total synthesis of this compoundwas carried out.3-Methoxy-4,5-dihydroxy-methyl benzoate was used as starting material ,the targetmolecule was synthesized via a reaction sequence of 9 steps in an overall yield of 16.3%. Thiscompound was characterized by ¹HNMR,IR,¹³CNMR and MS and was found to have nohepatoprotective activity in preliminary pharmacological tests.