Abstract: Immunization of inbred strain 615 mice with oleum Curcuma aromatica treated L 615 leukemic cells provided significant protection against subsequent challenge with alive L 615 leukemic cells.It was found that such acquired antitumor immunity was apparently tumor specific, rather stable and could be passively transferred to recipient L 615 mice by injection of spleen cell suspension of actively immunized mouse.Our study provided some experimental evidence for the possible mechanism of antitumor action of Curcuma aromatica and also raised the possibility of using tumor cells pretreated with Chinese herbal antitumor agents in immunotherapy of cancer.