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    Targeting protein folding and post-translational modifications by small molecules: review and prospects
    HE Yan-yi, YOU Qi-dong, WANG Lei
    2024, 59(11):2897-2911. DOI:10.16438/j.0513-4870.2024-0503
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    Small-molecule drug design strategies for regulating protein phosphorylation modification
    YANG Wen-yan, WANG Jia-yi, LIN Feng-jiao, WANG Ke-ran, WU Yu-zhuo, WANG Zhao-cheng, YOU Qi-dong, WANG Lei, ZHANG Qiu-yue
    2024, 59(11):2912-2925. DOI:10.16438/j.0513-4870.2024-0141
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    Advances in the development of novel E3 ubiquitin ligase ligands
    WANG Chen-xi, LU Yang, DONG Xiao-wu, CHE Jin-xin
    2024, 59(11):2926-2940. DOI:10.16438/j.0513-4870.2024-0093
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    Research progress on the roles and inhibitors of deubiquitinase USP28 in tumors
    LI Xing, ZHANG Bo-ya, LU Li-ting, WANG Yan, WEN Shuai, ZANG Yong-jun, XU Xiang-ming, MOU Yi
    2024, 59(11):2941-2952. DOI:10.16438/j.0513-4870.2024-0098
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    Chemically mediated 14-3-3 protein post-translational modification interference: design of molecular glue and the application in cancer treatment
    WU Liu-yi, LI Long-jing, TIAN Yu-cheng, XU Qian-qian, WEI Wei, LI Zhi-yu, BIAN Jin-lei
    2024, 59(11):2953-2961. DOI:10.16438/j.0513-4870.2024-0418
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    Current status and perspectives of small molecule inhibitors of heat shock protein 70
    ZHU Jin-yan, HE Ming-hui, WU Fan, YU Ying-lan, LUO Lei, SHAO Hao
    2024, 59(11):2962-2974. DOI:10.16438/j.0513-4870.2024-0462
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    HSP90 functional site recognition mechanism based on peptide derivatives
    ZHANG Li-xiao, YOU Qi-dong, WANG Lei
    2024, 59(11):2975-2980. DOI:10.16438/j.0513-4870.2024-0602
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    Activity evaluation and mechanism study of antibacterial-anti-inflammatory bifunctional Dioscoreae Nipponicae Rhizoma natural components targeting regulatory protein posttranslational modification
    SHEN Ru-xu, YE Zi-chen, ZHAO Jia-qi, ZHANG Qian, TANG Hai-feng, QU Di
    2024, 59(11):2981-2989. DOI:10.16438/j.0513-4870.2024-0428
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    Development of hydrophobic tag-based protein degraders for Bcl-2/Mcl-1 ubiquitination degradation
    WANG Zhe-ming, LI Yi-tong, WANG Zi-qian, ZHANG Zhi-chao
    2024, 59(11):2990-2996. DOI:10.16438/j.0513-4870.2024-0659
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    Design, synthesis and biological evaluation of novel AhR agonists
    JIA Jian-min, CAI Ya-xian, HAN Zi-xing, XU Jia-jia, CAI Kai-ming, HU Xiao-hui
    2024, 59(11):2997-3005. DOI:10.16438/j.0513-4870.2024-0517
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    Design, synthesis and biological activity study of thiazolehydrazone-based small molecule inhibitors of IGF2BP2
    ZHANG Shi-di, MA Sai, WANG Ying-zhe, CAI Yuan-qian, ZHANG Yan, YOU Qi-dong, GUO Xiao-ke
    2024, 59(11):3006-3016. DOI:10.16438/j.0513-4870.2024-0564
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    Design, synthesis and biological evaluation of saccharin-based HDACs inhibitors for the treatment of triple-negative breast cancer
    LI Xiao-meng, QUAN Meng-yao, LIU Yu-chen, HOU Xu-ben, HAN Lei-qiang, FANG Hao
    2024, 59(11):3017-3026. DOI:10.16438/j.0513-4870.2024-0562
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    Traditional Chinese medicine regulates the gut microbiota-bile acids-FXR axis to intervene in the development of colorectal cancer
    WANG Ya-ni, ZHANG Xiao-yu, LIU Yu-ping, QIN Xiao-ying, HUO Jie-ge, CHEN Yan, ZHANG Huang-qin
    2024, 59(11):3027-3041. DOI:10.16438/j.0513-4870.2024-0568
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    A new model for screening active ingredients in traditional Chinese medicine based on the interactions between gut microorganisms and G protein-coupled receptor
    LIU Chang-min, ZHENG Yi-xuan, YU Jing-sheng, WANG Hui, CHEN Shi-lin, SONG Chi
    2024, 59(11):3042-3056. DOI:10.16438/j.0513-4870.2024-0333
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    Advances in research of dual inhibitors targeting Janus kinase and histone deacetylase
    SHEN Jing, HU Wei-jie, DONG Guo-qiang, SHENG Chun-quan, HUANG Ya-hui
    2024, 59(11):3057-3073. DOI:10.16438/j.0513-4870.2024-0263
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    Research progress on mRNA pulmonary delivery systems
    CHEN Ze-hong, ZHANG Xin-yu, XING Hao-nan, LU Mei, MENG Fan, LI Jing-ru, GAO Xiu-li, ZHENG Ai-ping
    2024, 59(11):3074-3084. DOI:10.16438/j.0513-4870.2024-0139
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    Carboxyamidotriazole ameliorates experimental psoriasis via downregulating the expressions of cytokines and antimicrobial peptide S100A7
    LIU Jing-wen, YANG Mei, ZHU Lei
    2024, 59(11):3085-3093. DOI:10.16438/j.0513-4870.2024-0583
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    Therapeutic effect of QiShenYiQi Dripping Pills on mice with heart failure with preserved ejection fraction
    ZHANG Zhen-zhen, WANG Meng-yao, HAN Yan-lu, HU Yun-hui, LI Xiao-qiang, GUO Kai-min, DUAN Ya-jun, ZHANG Shuang
    2024, 59(11):3094-3103. DOI:10.16438/j.0513-4870.2024-0599
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    Effects of probiotics and docosahexaenoic acid on learning memory and brain damage in Aβ25-35-induced Alzheimer's disease mice
    HAO Feng-xiao, ZENG Meng-nan, CAO Bing, LIANG Xi-wen, YE Kai-li, JIAO Xin-mian, FENG Wei-sheng, ZHENG Xiao-ke
    2024, 59(11):3104-3116. DOI:10.16438/j.0513-4870.2024-0634
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    Cerebroprotein hydrolysate oral liquid alleviates ischemic stroke through improving lipid metabolism abnormalities
    YU Teng-jie, ZHANG Ting-ting, LIU Ye, CHENG Dong, AI Hao-yu, JIA Nan, XIE Lin, WANG Guang-ji, LIANG Yan
    2024, 59(11):3117-3129. DOI:10.16438/j.0513-4870.2024-0636
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    Phenolic acid compounds from Phellodendron chinense and their activity on α-glucosidase inhibition
    ZHANG Yu-lin, LI Si-qi, ZHU Lan-zhu, CHEN Xuan-qin
    2024, 59(11):3130-3134. DOI:10.16438/j.0513-4870.2024-0329
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    Chemical consitituents and hypoglycemic activity of Sophora tonkinensis
    YAN Xiao-yun, QIN Ling-feng, ZHANG Rui, YANG Ya-nan, TIAN Jin-ying, YE Fei, ZHANG Xu, ZHANG Pei-cheng, WANG Guo-cheng
    2024, 59(11):3135-3140. DOI:10.16438/j.0513-4870.2024-0549
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    Identify the metabolites of total saponins of Platycodonis Radix in blood based on intestinal bacteria-mediated method
    WU Xi-wa, ZHANG Xin-yu, ZHONG Yuan-han, ZHANG Xue-mei, ZHOU Yu, FENG Yan, QIN Qian, ZHANG Shou-wen, ZHONG Guo-yue, ZENG Jin-xiang
    2024, 59(11):3141-3152. DOI:10.16438/j.0513-4870.2024-0377
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    Gene cloning, functional identification, structural and expression analysis of sucrose synthase from Cistanche tubulosa
    TIAN Wei-sheng, YAN Ya-ru, CUI Xiao-xue, WANG Ying-xia, HUANG Wen-qian, ZHAO Sai-jing, LI Jun, SHI She-po, TU Peng-fei, LIU Xiao
    2024, 59(11):3153-3163. DOI:10.16438/j.0513-4870.2024-0069
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    Structural characteristics and phylogenetic analysis of chloroplast genomes of four species of Lonicera
    XIONG Yao, TONG Ling-fei, CAO Lan, MU Ze-jing, SHEN Cheng-ying, DU Xiao-lang
    2024, 59(11):3164-3171. DOI:10.16438/j.0513-4870.2024-0306
    Abstract PDF
    2024, 59(11):3172-3178. DOI:10.16438/j.0513-4870.2020-1815
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