2,3-Dihydro-1H-pyrrolo3,2-cquinoline and 2,3,5,9b-tetrahydro-1Hpyrrolo3,2-c-quinoline derivatives: synthesis and their inhibitory activity against Kv2.1

Fourteen new compounds with 2,3-dihydro-1H-pyrrolo3,2-c-quinoline or 2,3,5,9b-tetrahydro- 1H-pyrrolo3,2-cquinoline scaffold were designed and synthesized, and their inhibitory activities against Kv2.1 were evaluated. As a result, 2,3-dihydro-1H-pyrrolo3,2-cquinoline derivatives 3a and 5a were identified as potent inhibitors of Kv2.1 with IC₅₀ values of 10.2 and 9.0 μmol·L^-1, respectively.