Five new gingerol compounds from Zingiberis Rhizoma

We separated and purified five chemical constituents of dried ginger by Diaion HP-20, Sephadex LH-20, silica gel and semi-preparative high performance liquid chromatography. Five gingerols were identified by physicochemical properties and MS and NMR spectroscopy techniques:4-(2-butyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (1), 4-(2-hexyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (2), 1-(4-hydroxy-3-methoxyphenyl)tridecane-3,5-diol (3),10-gingerdiol (4) and 1-1-(4-hydroxy-3-methoxy phenyl)-3-oxodecan-5-ylpyrrolidin-2-one (5a, 5b). Compounds 1-3, 5a, 5b are new compounds.