Research progress on the changes and mechanism of intestinal drug transporters in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a disease characterized by chronic and progressive inflammation of the intestinal tract, which seriously affects the quality of life of patients because it is difficult to cure and easy to recur. As the main organ of substance absorption, the changes of intestinal drug transporters will lead to changes in the behavior of endogenous and exogenous substances in vivo. Changes in the expression and function of a variety of drug transporters have also been observed in intestinal inflammatory tissues of patients with IBD. This paper reviews the changes of intestinal drug transporters in IBD and its related mechanisms, which provides a theoretical basis for finding new strategies for the treatment of IBD and clinical rational drug use.