Two new compounds from Smilax glabra Roxb.

Twenty compounds were isolated from the ethyl acetate extract of Smilax glabra by using various chromatographic techniques, including macroreticular resin, silica gel, Sephadex LH-20 and semi-preparative HPLC. Their structures were elucidated by physicochemical properties, MS and spectroscopic data. These compounds were elucidated as glabraside A (1), glabraone A (2), 5-hydroxy-3ʹ,4ʹ,7-trimethoxy-flavanone (3), naringenin (4), quercetin 7-O-α-L-rhamnoside (5), neoastilbin (6), neoisoastilbin (7), isoastilbin (8), eriodictyol-7-O-β-D-glucopyranoside (9), naringenin-7-O-α-L-rhamnoside (10), kaempferol 3-O-4'''''-O-acetyl-α-L-rhamnosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (11), 5-hydroxymaltol (12), 3,4,5-trimethoxyphenyl-1-O-β-D-glucopyranoside (13), 2-(3',4'-dihydroxyphenyl)-1,3-benzodioxole-5-aldehyde (14), kompasinol A (15), (+)-syringaresinol (16), cis-resveratrol (17), trans-resveratrol (18), flufuran (19) and 5-hydroxymethyl-furaldehyde (20). Two new compounds (1 and 2) showed inhibitory activity toward nitric oxide (NO) production, with IC₅₀ values of 56.8 and 29.5 μmol·L^-1, respectively.